Structural characterization of a blood group A heptaglycosylceramide with globo‐series structure

FEBS Letters

Breimer, Michael E.¹  Joval, Per-Åke² 

[1] Department of Surgery I, University of Göteborg, Sahlgrens Hospital, 413 45 Göteborg, Sweden;Department of Biochemistry, University of Göteborg and Chalmers Institute of Technology, S-412 96 Göteborg, Sweden

关键词: Blood group A;    Glycolipid;    Globo-series;    Human kidney;   

DOI  :  10.1016/0014-5793(85)80213-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A blood group A glycosphingolipid with the globo-series structure has been isolated from human kidney and structurally characterized. The structure was shown by mass spectrometry and proton NMR spectroscopy of the intact permethylated and permethylated-reduced derivatives together with degradation studies to be, GalNAcαl → 3Gal(2 ←1αFuc)β1 → 3GalNAcβ1 → 3Galα1 → 4Galαβ1 → 4Glcβ1 → 1 Ceramide. This glycolipid reacts with both polyclonal and monoclonal anti-A blood group typing antisera and it is the major glycolipid based blood group A antigen present in the human kidney.

【 授权许可】

Unknown