Lipid vesicle formation: the transition from open disks to closed shells

FEBS Letters

Ruppel, Diether¹  Fromherz, Peter¹ 

[1] Abteilung Biophysik der Universität Ulm, D-7900 Ulm-Eselsberg, FRG

关键词: Vesicle;    Lecithin;    Cholate;    Bilayer;   

DOI  :  10.1016/0014-5793(85)80211-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The relaxation of a lecithin suspension after sonication is studied by electron microscopy. It is shown that vesicles are formed in a two-stage process: Fragmentation into open sheets of bilayer under the action of sound and subsequent spontaneous closure of the planar disks into closed shells. A prerequisite of the discovery is a slowing down of the relaxation process by the addition of a moderate amount of cholate as an ‘edge-actant’.

【 授权许可】

Unknown