Effect of Hydrogenated Lecithin on Cytotoxicity of Liposome

Bulletin of the Korean chemical society

Jae Sup Shin¹  Soo Jin Park¹  Duck Hwan Bae¹  Fan Long Jin¹  Gwi Su Shin¹ 

关键词: Lecithin;    Liposome;    Particle size;    Turbidity;    Cytotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In this study, a hydrogenated lecithin-containing liposome was prepared using a sonicator and microfluidizer at high shear. The surface tension, particle size, turbidity, and transition temperature (Tc) of the liposome were investigated and compared with the commercially available standard surfactant Tween-60. The cytotoxicities were characterized using the MTT method. The surface tension of hydrogenated lecithin was found to be higher than that of Tween-60. The particle size prepared at above Tc was smaller than that prepared below Tc. The results of the cytotoxicity experiment indicated that Lecinol 10 exhibits the highest IC50 value, which shows its high safety in this study.

【 授权许可】

Unknown