Pulse‐radiolysis study of daunorubicin redox cycles

FEBS Letters

Houée-Levin, C.¹  Gardès-Albert, M.¹  Ferradini, C.¹  Faraggi, M.²  Klapper, M.² 

[1] Laboratoire de Chimie Physique, Université René Descartes, 45, rue des Saint-Pères, 75270 Paris Cedex 06, France;Department of Chemistry, The Ohio State University, 140 West 18th Avenue, Columbus, OH 43210, USA

关键词: Daunorubicin;    Pulse radiolysis;    Free radical;    Semiquinone;    Hydroquinone;    Redox cycle;    DOS;    daunorubicin;    DOS.−1;    semiquinone daunorubicin;    DH2OS;    hydroquinone daunorubicin;   

DOI  :  10.1016/0014-5793(85)80188-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Daunorubicin aqueous solutions were reduced by COO^.−1 or e_aq ⁻¹ free radicals produced by pulse radiolysis. The kinetics of the semiquinone radical formation and decay were studied. The semiquinone disproportionation leads to a pseudo-equilibrium between the drug, its semiquinone and hydroquinone reduced states (K _eq = 30 at pH 7), which lasts a few hunderd milliseconds and which is destroyed by the hydroquinone glycosidic cleavage. Consequences concerning daunorubicin antitumour action are briefly discussed.

【 授权许可】

Unknown