Effects of growth hormone‐releasing factor and somatostatin on growth hormone secretion and cellular cyclic AMP levels

FEBS Letters

Law, Greg J.¹  Ray, Keith P.¹  Wallis, Michael¹ 

[1] Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, England

关键词: Growth hormone-releasing factor;    Growth hormone;    Somatostatin;    Cyclic AMP;    Rat pituitary cell;    Sheep pituitary cell;    GRF;    growth hormone-releasing factor;    SRIF;    somatostatin;    GH;    growth hormone;   

DOI  :  10.1016/0014-5793(85)80180-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human pancreatic growth hormone-releasing factor (GRF-44-NH₂) stimulated growth hormone (GH) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat. Somatostatin (SRIF), over a wide range of doses and time, showed no significant effect on the elevated cyclic AMP levels in sheep cells, but did block the GH release in a dose-dependent manner. In rat cells, however, SRIF inhibited GRF-stimulated cyclic AMP levels by 75% maximum (still 8-fold greater than the basal levels) and GH release to almost half the basal value. We conclude that somatostatin inhibits GRF-elevated cyclic AMP levels in rat pituitary cells but not in sheep cells.

【 授权许可】

Unknown