期刊论文详细信息
FEBS Letters | |
Hb Marseille [α2β2 N methionyl ‐ 2 (NA2) His → Pro]: a new β chain variant having an extended N‐terminus | |
Blouquit, Y.1  Lena, D.1  Galacteros, F.1  Lacombe, C.1  Vovan, L.2  Arous, N.1  Delanoe-Garin, J.1  Bardakdjian, J.1  Orsini, A.2  Rosa, J.1  | |
[1] INSERM U.91, Hôpital Henri Mondor, 94010 Creteil, France;Institut de Pédiatrie, Hôpital de la Timone, 13000 Marseille, France | |
关键词: Hemoglobinopathy; β variant; HPLC Hemoglobin Marseille; Protein synthesis; | |
DOI : 10.1016/0014-5793(84)80624-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal β chain, high pressure liquid chromatography of the corresponding tryptic peptides and then microsequencing of the abnormal T1. These procedures revealed a double abnormality: the presence of a methionyl residue extending the NH2 terminus and a histidine to proline substitution in position NA2.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020286188ZK.pdf | 392KB | download |