Interaction of α2‐macroglobulin‐bound thrombin with hirudin

FEBS Letters

Steinbuch, Marion²  Pochon, François¹ 

[1] U.219 INSERM, Institut Curie - Biologie, Campus Universitaire, 91405 OrsayFrance;Centre National de Transfusion Sanguine, 91400 Orsay, France

关键词: α2-Macroglobulin;    Thrombin;    Hirudin;   

DOI  :  10.1016/0014-5793(84)80991-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The human thrombin bound to α₂-macroglobulin (α₂ M) in a 1:1 stoichiometry is still able to interact with one of its specific inhibitors, hirudin. The dissociation constant of the complex hirudin-α₂M-bound thrombin is 1 × 10⁻⁷ M, whatever the mode of thrombin binding, covalent or non-covalent.

【 授权许可】

Unknown