A developmentally regulated disappearance of slow myosin in fast‐type muscles of the mouse

FEBS Letters

Bryers, Paul S.²  Johnstone, Donna²  Butler-Browne, Gillian S.¹  Ecob, Marion S.²  Jaros, Evelyn²  Whalen, Robert G.¹ 

[1] Département de Biologie Moléculaire, Institut Pasteur, 25 Rue du Dr. Roux, 75724 Paris, France;Muscular Dystrophy Group Laboratories, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, England

关键词: Histochemistry;    Immunocytochemistry;    EDL;    Semimembranosus;    129 Mouse;   

DOI  :  10.1016/0014-5793(84)80979-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Histochemistry and immunocytochemistry using an antibody to adult rat slow-type myosin demonstrated that about 10% of the fibers in the mouse extensor digitorum longus and semimembranosus muscles contain slow myosin during the first month after birth. In adult animals, these muscles have only 0–0.8% slow myosin-containing fibers. These results demonstrate a developmentally linked disappearance of an adult-type myosin, and show that the adult phenotype of muscle fibers is not necessarily determined before birth as previously suggested.

【 授权许可】

Unknown