Inositol trisphosphate activates pyruvate dehydrogenase in isolated fat cells

FEBS Letters

Wieland, O.H.¹  Koepfer-Hobelsberger, B.¹ 

[1] Institut für Klinische Chemie und Forschergruppe Diabetes, Städtisches Krankenhaus München-Schwabing, Kölner Platz 1, 8000 München 40, FRG

关键词: Insulin mediator;    PDH activation;    Inositol phosphate;    Ca2+-mobilisation;    Isolated fat cell;   

DOI  :  10.1016/0014-5793(84)81208-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inositol trisphosphate, when added to permeabilized rat fat cells, led to a several-fold increase of pyruvate dehydrogenase activity due to conversion of the inactive phospho form (PDHb) to the active, dephospho form (PDHa). It is suggested that inositol trisphosphate, probably through intracellular Ca²⁺-mobilisation, acts as a physiological mediator of insulin for activation of the mitochondrial PDH-complex.

【 授权许可】

Unknown