Evidence for direct interactions between methimazole and free radicals

FEBS Letters

Kendall-Taylor, P.²  Taylor, J.J.²  Willson, R.L.¹ 

[1] Department of Biochemistry, Brunel University, Uxbridge UB8 3PH, Middlesex, England;Department of Medicine, Wellcome Research Laboratories, Royal Victoria Infirmary, University of Newcastle upon Tyne, Newcastle upon Tyne NEI 4LP England

关键词: Thyroid;    Free radical;    Iodine;    Antithyroid drug;   

DOI  :  10.1016/0014-5793(84)81192-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two experimental approaches have been used to investigate possible interactions of methimazole with hydroxyl (OH) and iodine (I₂ ⁻) free radicals. Methimazole protects sensitive enzymes against inactivation caused by OH and I₂ ⁻ Pulse radiolysis reveals the presence of transient absorbing species formed as a result of the direct interaction between methimazole and these free radicals. Measurements of the absolute rate constants indicate that these reactions proceed very rapidly at very low drug concentrations. These experiments provide direct evidence that methimazole is a potent scavenger of OH and I₂ ⁻ and they provide a possible explanation for the previously observed effects of this drug.

【 授权许可】

Unknown