The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin

FEBS Letters

Cochran, M.¹  Neoh, S.¹  Coates, J.¹ 

[1] Department of Medicine and Immunology, Flinders Medical Centre, Bedford Park, 5042 Australia

关键词: Human transferrin;    Aluminium binding constant;    Molar relationship;    Aluminium-iron competition;    OD240;    optical density at 240 nm;   

DOI  :  10.1016/0014-5793(84)80926-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human transferrin is shown to bind 2 mol of aluminium per mol of protein using spectrophotometric titration. Competitive equilibrium between aluminium and ferric ions for transferrin binding sites is observed, and a value of 2.5 (± 0.4) × 10¹⁵ M⁻¹ is found for the apparent binding constant under physiological conditions.

【 授权许可】

Unknown