The effect of anion channel blockers on enzymatic activity of Na+/K+‐ATPase and the electrogenic Na+/K+ pump

FEBS Letters

Vyskočil, F.¹  Teisinger, J.²  Zemková, H.² 

[1] Physiological Institute, Czechoslovak Academy of Sciences, Prague, Czechoslovakia;Institute of Hygiene and Epidemiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

关键词: Brain microsome;    Skeletal muscle;    Na+/K+-ATPase;    Electrogenic Na+/K+ pump;    Membrane resistance;    Disulfonic stilbene;    DIDS;    4-acetamido-4'-isothiocyano-2;    2'-stilbene disulfonic acid;    SITS;    4;    4 '-diisothiocyano-2;    2'-stilbene disulfonic acid;    DNDS;    4;    4'-dinitro-2;    2'-stilbene disulfonic acid;    DES;    diethylstilbestrol;    PATAS;    4;    4 ' -bis-4-phenylamino-6-(2-hydroxyethyl)amino-5-triazin-2-yl amino-2;    2'-stilbene disulfonic acid;   

DOI  :  10.1016/0014-5793(84)80750-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Disulfonic stilbenes which block the anion-transport in red blood cells were found to inhibit the brain microsomal Na⁺/K⁺-ATPase but not the electrogenic Na⁺/K⁺ pump in intact muscle cells. In contrast to the anion-transport system, the Na⁺/K⁺-ATPase is inhibited by disulfonic stilbenes, apparently from the cytoplasmic side of the membrane. The pathways for anion and active cation transport are thus different but similar groups of sulfhydryl and/or amino acid residues must play an important role in both systems.

【 授权许可】

Unknown