Calmodulin may mediate 1,25‐dihydroxyvitamin D‐stimulated intestinal calcium transport

FEBS Letters

Chafouleas, James¹  Munson, Scott²  Bikle, Daniel D² 

[1] Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA;Department of Medicine (IIIN), VA Medical Center and University of California, 4150 Clement Street, San Francisco, CA 94121 USA

关键词: Calcium transport;    Intestine;    Brush border membrane;    1;    25-Dihydroxyvitamin D;    Calmodulin;    Calmodulin antagonist;   

DOI  :  10.1016/0014-5793(84)81071-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

1,25-Dihydroxyvitamin D (1,25(OH)₂D) stimulated an increase in calmodulin content in chick duodenal brush border membranes in parallel with an increase in duodenal calcium transport in vivo and calcium uptake by brush border membrane vesicles (BBMV) in vitro. The increase in calcium uptake by BBMV was blocked by specific calmodulin antagonists. These results suggest that calmodulin mediates 1,25(OH)₂D-stimulated calcium movement across the brush border membrane.

【 授权许可】

Unknown