Chaotic dynamics in yeast glycolysis under periodic substrate input flux

FEBS Letters

Kuschmitz, Dietrich¹  Hess, Benno¹  Markus, Mario¹ 

[1] Max-Planck-Institut für Ernährungsphysiologie, Rheinlanddamm 201, 4600 Dortmund 1, FRG

关键词: Oscillation;    Chaos;    Entrainment;    Glycolysis;    Yeast;    PFK;    phosphofructokinase(EC2.7.1.11);    PK;    pyruvate kinase (EC 2.7.1.40);    FBP;    fructose 1;    6-bisphosphate;    F6P;    fructose 6-phosphate;    PEP;    phosphoeno/pyruvate;    [Ktot] and [Mgtot];    total concentrations (bound plus unbound) of potassium and magnesium;    F;    NADH fluorescence in arbitrary units;    ωe;    T e;    frequency and period of the externally (e) applied flux;    ω;    T;    frequency and period of the system response;    ω0. T 0;    frequency and period of the system at constant input flux;    i.e.;    without periodic excitation;   

DOI  :  10.1016/0014-5793(84)81132-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The numerical analysis for a glycolytic model containing the enzymes phosphofructokinase and pyruvate kinase reveals different types of entrainment, as well as chaotic response under sinusoidal substrate input. Entrainment with response periods 1, 2, 3, 5 and 7-times the input flux period and aperiodic behaviour is verified by measurements of NADH fluorescence in extracts of Saccharomyces cerevisiae in the theoretically predicted range. The stroboscopic transfer function obtained from the aperiodic signal admits period 3, implying chaos according to the Li-Yorke theorem.

【 授权许可】

Unknown