Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex

FEBS Letters

Sinha, Birandra K.¹  Myers, Charles E.¹  Muindi, Josephia R.F.¹  Gianni, Luca¹ 

[1] Clinical Pharmacology Branch, Clinical Oncology Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Anthracycline-iron complex;    DNA damage;    Spin trapping;    Hydroxyl radical;   

DOI  :  10.1016/0014-5793(84)81130-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adriamycin-Fe³⁺ complex catalyzes the formation of hydroxyl radical from hydrogen peroxide but the DNA-adriamycin-iron ternary complex is much more effective. 11-Deoxyadriamycin, which shows no spectral evidence of complex formation with iron, was ineffective. The generation of hydroxyl radical by adriamycin-Fe³⁺ complex in the presence of DNA correlates with its ability to cleave DNA. Hydroxyl radicals are thus implicated as the reactive oxygen species involved in the DNA damage caused by the adriamycin-Fe³⁺ complex.

【 授权许可】

Unknown