Determination of the size of the packing defects in dimyristoylphosphatidylcholine bilayers, present at the phase transition temperature

FEBS Letters

de Gier, Johannes¹  de Kruijff, Ben¹  van Hoogevest, Peter¹ 

[1] Department of Biochemistry and Institute of Molecular Biology, State University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands

关键词: Dimyristoylphosphatidylcholine;    Vesicle;    Bilayer permeability;    Phase transition temperature;    Pore size;    DOPC;    dioleoylphosphatidylcholine;    TEMPO;    2;    2;    6;    6-tetramethylpiperidine N-oxyl;   

DOI  :  10.1016/0014-5793(84)80479-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Multilamellar liposomes of dimyristoylphosphatidylcholine, containing 4 mol% egg phosphatidic acid show at the phase transition temperature an increased permeability for non-electrolytes of M _r values up to 900. This indicates that the packing defects occurring at the liquid crystalline/gel state phase boundary have a similar pore diameter (15–18 A) as the packing defects present in glycophorin—dioleoylphos-phatidylcholine vesicles. This suggests that packing defects at the protein—lipid interphase are the major permeation pathway of the glycophorin—dioleoylphosphatidylcholine vesicles.

【 授权许可】

Unknown