New functions for the components of glucocorticoid receptor apparatus?

FEBS Letters

Medvedeva, L.A.¹  Shnyra, A.A.¹  Seleznev, Yu.M.¹ 

[1] USSR Cardiology Research Center, Petroverigsky Lane, 10, Moscow 101837, USSR

关键词: Heart;    Myocardium;    Liver;    Hormone;    Glucocorticoid;    Glucocorticoid receptor;   

DOI  :  10.1016/0014-5793(84)80471-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

By ammonium sulphate precipitation, phosphocellulose and DEAE—Sephacel chromatography and Sephadex G-75 gel filtration, a factor was separated from rat liver cytosol which was shown to suppress the inhibitory effect of the steroid deoxycorticosterone (DOC) on the specific [³H]glucocorticoid binding to cytoplasmic receptors. By SDS-polyacrylamide gel electrophoresis (SDS—PAGE) of factor-containing fractions its M _r was suggested to be about 40000. The possible role of this factor in the regulation of glucocorticoid receptor apparatus function is discussed.

【 授权许可】

Unknown