Possible bioactive conformations of α‐melanotropin

FEBS Letters

Rozenblit, S.A.¹  Nikiforovich, G.V.¹  Shenderovich, M.D.¹  Chipens, G.I.¹ 

[1] Institute of Organic Synthesis, Latvian SSR Academy of Sciences, 226006 Aizkraukles 21, Riga, USSR

关键词: α-Melanotropin;    Energy calculation;    Conformation-function relationship;    Cyclic analog;    Melanotropic activity;   

DOI  :  10.1016/0014-5793(84)81335-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

By comparing the results of energy calculation for α-MSH and its semirigid analogues , , and , a detailed description of two possible bioactive conformations for the ‘specific’ central site of α-MSH_6–9 is proposed representing variants of chain-reversal structure. A possible explanation of the rise in melanotropic activity of the latter two semirigid analogues is presented.

【 授权许可】

Unknown