Equilibrium of conformers in solution: spin‐labelled angiotensin

FEBS Letters

Nikiforovich, G.V.¹  Sekacis, I.¹  Podiņš, L.¹  Bētiņš, J.¹  Vesterman, B.¹ 

[1] Institute of Organic Synthesis, Latvian SSR Academy of Sciences, 226006 Riga, Aizkraukles 21, USSR

关键词: Energy calculation;    Angiotensin;    NMR relaxation;    Peptide solution conformation;   

DOI  :  10.1016/0014-5793(85)80057-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The number of structural parameters were determined for spin-labelled angiotensin in aqueous solution with the use of fluorescence spectroscopy and ¹H NMR relaxation induced by the spin label. At the same time all measured parameters were estimated theoretically by means of energy calculations and Monte-Carlo techniques. The matching procedure for experimental and computational data allows one to suggest a dynamic equilibrium between conformers of the molecule in aqueous solution and to estimate the values of their weights.

【 授权许可】

Unknown