The effect of lipopolysaccharide on lipid bilayer permeability of β‐lactam antibiotics

FEBS Letters

Yamaguchi, Akihito¹  Sawai, Tetsuo¹  Hiruma, Ryoichi¹ 

[1] Division of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Chiba 260, Japan

关键词: β-Lactam;    Outer membrane;    Lipopolysaccharide;    Permeability;    Liposome;    Hydrophobicity;   

DOI  :  10.1016/0014-5793(84)81326-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The lipid-bilayer permeability of cephalosporins was extensively suppressed by addition of lipopolysaccharide to liposomal membrane in proportion to the hydrophobicity of the drugs. This suggests that the polysaccharide chain layer contributes to the barrier function. The importance of the polysaccharide chain in the barrier function was also supported by the fact that the permeability to Rd-type lipopolysaccharide-containing liposomes showed essentially the same dependency on the hydrophobicity of the cephalosporins as that of the lipopolysaccharide-free liposomes. In this case the permeability of the cephalosporins was proportional to their hydrophobicity. Similar lipopolysaccharide effect was also observed in the permeation of penicillins.

【 授权许可】

Unknown