Three‐dimensional structure of monoanionic methionine‐enkephalin: X‐ray structure of tert‐butyloxycarbonyl‐Tyr‐Gly‐Gly‐(4‐bromo)Phe‐Met‐OH

FEBS Letters

Tomita, Ken-ichi²  Doi, Mitsunobu³  Sakakibara, Shunpei¹  Inoue, Masatoshi³  Kimura, Terutoshi¹  Fujiwara, Takaji²  Ishida, Toshimasa³ 

[1] Protein Research Foundation, 476 Ina, Minoh, Osaka 562, Japan;Faculty of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka 565 Japan;Department of Physical Chemistry, Osaka College of Pharmacy, 10-65, 2-Kawai, Matsubara-City, Osaka 580, Japan

关键词: Met-enkephalin analog;    Anionic form;    X-ray analysis;    Solid state;    Extended conformation;    β-Sheet;    Boc-Enke;    tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH;    Met-enkephalin;    H-Tyr-Gly-Gly-Phe-Met-OH;    Leu-enkephalin;    H-Tyr-Gly-Gly-Phe-Leu-OH;    Boc;    tert-butyloxycarbonyl;   

DOI  :  10.1016/0014-5793(84)81318-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The conformation of tert-butyloxycarbonyl-Tyr-Gly-Gly-(4-bromo)Phe-Met-OH, as a monoanionic derivative of Met-enkephalin, was elucidated by X-ray crystal analysis. The molecule took an extended conformation which was bended at the Phe residue. The implication of the dimer formation caused by 4 intermolecular hydrogen bonds was discussed in the relation with the opiate receptor.

【 授权许可】

Unknown