Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini

FEBS Letters

de Pont, J.J.H.H.M.¹  Fleuren-Jakobs, A.M.M.¹ 

[1] Department of Biochemistry, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands

关键词: Secretion;    Amylase;    Pancreas;    Phorbol ester;    A23187;    Protein kinase C;    class=“abr”TPA;    12-O-tetradecanoyl-phorbol-13-acetate;   

DOI  :  10.1016/0014-5793(84)81369-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.

【 授权许可】

Unknown