24R,25‐Dihydroxyvitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture

FEBS Letters

Kaye, Alvin M.¹  Sömjen, Dalia²  Binderman, Itzhak² 

[1] Department of Hormone Research, The Weizmann Institute of Science, Rehovot 76100, Israel;Hard Tissues, Ichilov Hospital, Tel-Aviv Medical Center 64239 and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Israel

关键词: 24R;    25-Dihydroxycholecalciferol;    Creatine kinase BB;    Chicken cartilage;    Limb bud;    Estrogen-induced protein;    D3;    cholecalciferol;    in all metabolites (e.g.;    24R;    25(OH)2D3 = 24R;    25(OH)2 cholecalciferol);    ODC;    ornithine decarboxylase;    BUdr;    bromodeoxyuridine;   

DOI  :  10.1016/0014-5793(84)80143-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In chick limb-bud cartilage cell cultures 24R,25-dihydroxycholecalciferol (24R,25(OH)₂D₃), but not 24S,25(OH)₂D₃, 1α,25(OH)₂D₃ or 25(OH)D₃, stimulates the activity of the brain type (BB) isozyme of creatine kinase (EC 2.7.3.2), the ‘estrogen-induced protein’ first identified in rat uterus. Cultures treated with bromodeoxyuridine, in which cartilage formation in inhibited, show no stimulation of creatine kinase BB by 24R,25(OH)₂D₃.

【 授权许可】

Unknown