期刊论文详细信息
FEBS Letters | |
ATP and other purine nucleotides stimulate the inactivation of ornithine transcarbamylase by broken lysosomes | |
Navarro, Alfonso1  Grisolía, Santiago1  | |
[1] Istituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Amadeo de Saboya 4, Valencia 10, Spain | |
关键词: Ornithine transcarbamylase; Lysosome; ATP; Carbamoyl phosphate; OTC; ornithine transcarbamylase; β-NAGASE; β-N-acetyl-D-glucosaminidase; BSA; bovine serum albumin; ϵ-ATP; 1-N 6-ethenoadenosine 5′-triphosphate; MSH; β-mercaptoethanol; | |
DOI : 10.1016/0014-5793(84)80138-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Ornithine transcarbamylase (OTC) is very stable in rat liver homogenates, or mitochondria. However, pure OTC from rat or beef liver is inactivated by broken lysosomes. ATP and a number of purine nucleotides, particularly ϵ-ATP, stimulate the inactivation of OTC by broken lysosomes. Inactivation of OTC by trypsin and elastase is also stimulated by ϵ-ATP. Carbamoyl phosphate protects OTC against proteolytic attack by elastase or by broken lysosomes. Thus, environmental factors, e.g., ATP and carbamoyl phosphate, appear to influence OTC stability to proteases.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020285240ZK.pdf | 330KB | download |