Novel inhibition of carbonic anhydrase isozymes I, II and III by carbamoyl phosphate

FEBS Letters

Chegwidden, W.R.²  Hewett-Emmett, D.¹  Tashian, R.E.¹  Shiels, A.³  Jeffery, S.³  Carter, N.D.³ 

[1] Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Department of Biological Sciences, Sheffield City Polytechnic, Sheffield S1 1WB England;Department of Child Health, St. George's Hospital Medical School, London SW17 ORE, England

关键词: Carbonic anhydrase isozyme;    Carbamoyl phosphate;    Carbamoyl phosphate synthetase;    Enzyme inhibition;    Urea cycle;   

DOI  :  10.1016/0014-5793(84)80168-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic anhydrase inhibitors discovered hitherto, in that it inhibits the 3 isozymes with equal effect, despite their strikingly different properties. The results imply the participation of carbonic anhydrase in the regulation of substrate availability for the urea cycle.

【 授权许可】

Unknown