FEBS Letters | |
Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats | |
Hernández-Sotomayor, S.M.Teresa2  García-Sáinz, J.Adolfo1  | |
[1] Departamento de Bioenergt́ica, Centro de Investigaciones en Fisilogía Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-600, 04510 México City, Mexico;Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado Postal 70-600, 04510 México City, Mexico | |
关键词: α1-Adrenergic receptor; Ureogenesis; β-Adrenergic receptor; Adrenalectomy; | |
DOI : 10.1016/0014-5793(84)80118-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through α1-adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both α1- and β-adrenoceptors are involved in the action of epinephrine. Furthermore, the α1-adrenergic-mediated stimulation of ureogenesis in these cells is dependent on the presence of extracellular calcium. Our results indicate that glucocorticoids modulate the calcium dependency of α1-adrenergic effects and are consistent with our suggestion that two pathways are involved in the transduction of the α1-adrenergic signal.
【 授权许可】
Unknown
【 预 览 】
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RO201912020285181ZK.pdf | 336KB | download |