Adrenergic regulation of ureogenesis in hepatocytes from adrenalectomized rats

FEBS Letters

Hernández-Sotomayor, S.M.Teresa²  García-Sáinz, J.Adolfo¹ 

[1] Departamento de Bioenergt́ica, Centro de Investigaciones en Fisilogía Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-600, 04510 México City, Mexico;Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Apartado Postal 70-600, 04510 México City, Mexico

关键词: α1-Adrenergic receptor;    Ureogenesis;    β-Adrenergic receptor;    Adrenalectomy;   

DOI  :  10.1016/0014-5793(84)80118-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In hepatocytes from control rats, the ureogenic action of epinephrine is mainly mediated through α₁-adrenoceptors and the effect is independent of the presence of extracellular calcium. In hepatocytes from adrenalectomized rats, both α₁- and β-adrenoceptors are involved in the action of epinephrine. Furthermore, the α₁-adrenergic-mediated stimulation of ureogenesis in these cells is dependent on the presence of extracellular calcium. Our results indicate that glucocorticoids modulate the calcium dependency of α₁-adrenergic effects and are consistent with our suggestion that two pathways are involved in the transduction of the α₁-adrenergic signal.

【 授权许可】

Unknown