Location of haem‐binding sites in the mitochondrial cytochrome b

FEBS Letters

Saraste, Matti¹ 

[1] Department of Medical Chemistry, University of Helsinki, Siltavuorenpenger 10 A, 00170 Helsinki 17, Finland

关键词: Membrane protein;    Mitochondria;    Cytochrome b;    Amino acid sequence;    Haem-binding site;   

DOI  :  10.1016/0014-5793(84)80114-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Amino acid sequences of 6 mitochondrial cytochromes b are analysed to locate the binding sites of the two protohaems. Four invariant histidines are found in two protein segments which span the membrane. In each, two histidines are separated by 13 residues. This would place them on the same sides of α-helices, and the protohaems could be sandwiched as bis-imidazole complexes between the two transmembrane segments. In this model the haems are located in different halves of the bilayer; the Fe–Fe distance is about 20 Å.

【 授权许可】

Unknown