Do hydrophobic sequences cleaved from cellular polypeptides induce membrane fusion reactions in vivo?

FEBS Letters

Lucy, Jack A.¹ 

[1] Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, University of London, Rowland Hill Street, London NW3 2PF, England

关键词: Membrane fusion;    Cell Fusion;    Calcium;    Membrane protein;    Proteolysis;    Hydrophobic polypeptide;   

DOI  :  10.1016/0014-5793(84)80085-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The concept that a direct interaction between Ca²⁺ and phospholipids is a major factor in membrane fusion reactions is questioned. Attention is drawn to a number of findings on associations between fusion and the proteolysis of membrane proteins. It is proposed that hydrophobic polypeptides, which are functionally comparable to the fusogenic proteins of certain viruses but which are produced in cells by the endogenous proteolysis of membrane and cellular proteins, may induce membrane fusion reactions in vivo.

【 授权许可】

Unknown