Decreased rate of fatty acid synthesis in brown adipose tissue of hypothalamic obese rats

FEBS Letters

Saito, Masayuki¹  Shimazu, Takashi¹ 

[1] Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu, Ehime 791-02, Japan

关键词: Brown adipose tissue;    Fatty acid synthesis;    Hypothalamic obesity;    Lipogenesis;    Thermogenesis;    Ventromedial hypothalamus;   

DOI  :  10.1016/0014-5793(84)80062-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Obese rats with lesions of the ventromedial hypothalamus (VMH) exhibited a 3-fold increase in the wet weight of interscapular brown adipose tissue (IBAT), due to an incresed triglyceride content, compared with lean controls. The rate of lipogenesis in IBAT was much higher than that in white adipose tissues in control rats, but decreased greatly in rats with VMH lesions and approximated the value in white adipose tissues. It was suggested that thermogenesis in BAT was impaired after VMH lesions by decreasing triglyceride turnover in BAT.

【 授权许可】

Unknown