CAPP‐calmodulin: A potent competitive inhibitor of calmodulin actions

FEBS Letters

Klee, Claude B.¹  Newton, Dianne L.¹ 

[1] Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Phosphodiesterase;    Myosin kinase;    Phenothiazine;    CAPP-calmodulin;    Calcineurin;    Protein phosphatase 2B;   

DOI  :  10.1016/0014-5793(84)80183-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A covalent adduct of norchlorpromazine (CAPP) and calmodulin is a very potent antagonist of calmodulin activation of several enzymes. The phenothiazine-calmodulin complex (CAPP-calmodulin) acts as a pure antagonist with phosphodiesterase and myosin kinase or a partial agonist with the phosphoprotein phosphatase, calcineurin. Because of its potency and the selectivity inherent to its calmodulin moiety, CAPP-calmodulin should be a uniquely useful probe of calmodulin actions.

【 授权许可】

Unknown