Synthesis of the nuclear protein cyclin in growing, senescent and morphologically transformed human skin fibroblasts

FEBS Letters

Bravo, Rodrigo¹  Celis, Julio E.¹ 

[1] Division of Biostructural Chemistry, Department of Chemistry, Aarhus University, DK-8000, Denmark

关键词: Transformation sensitive protein;    Cell proliferation;    Limited life span;    Two-dimensional gel electrophoresis;    IEF;    isoelectric focussing;   

DOI  :  10.1016/0014-5793(84)80006-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Quantitative two-dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin in normal human skin biopsies, growing and senescent fibroblasts and morphologically transformed skin fibroblasts (limited life span) has revealed a direct correlation between the levels of this protein and the proliferative state of the cells. These results strengthen the notion that cyclin may be a key component of the pathway(s) that control cell proliferation.

【 授权许可】

Unknown