Photogeneration of superoxide by adriamycin and daunomycin

FEBS Letters

Mossoba, Magdi M.¹  Riesz, Peter¹  Carmichael, Alsdair J.¹ 

[1] Radiation Oncology Branch, National Cancer Institute, Building 10, National Institutes of Health, Bethesda, MD 20205, USA

关键词: Adriamycin;    Daunomycin;    Superoxide;    Spin trapping;    DMPO;    4-MePyBN;   

DOI  :  10.1016/0014-5793(83)80325-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The hydroxyl and superoxide anion spin adducts of DMPO and 4-MePyBN, respectively, were obtained during photoirradiation of adriamycin and daunomycin solutions with visible light. Ethanol and dimethyl sulfoxide did not scavenge hydroxyl radicals in the photoirradiated drug solutions. Furthermore, the hydroxyl-DMPO spin adduct is not formed in the photolysis of air-free drug solutions, indicating that hydroxyl radicals are not directly produced in the photochemical reactions. Instead, the observed hydroxyl-DMPO is formed from the decay of the superoxide anion-DMPO spin adduct. The mechanism for generating the superoxide anion radical appears to be a direct electron transfer from the photoexcited adriamycin and daunomycin to dissolved oxygen.

【 授权许可】

Unknown