Fucosyltransferase activities in human lymphocytes and granulocytes

FEBS Letters

Ball, M.Geraldine¹  Greenwell, Pamela¹  Watkins, Winifred M.¹ 

[1] Division of Immunochemical Genetics, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ, England

关键词: Human blood;    Lymphocyte;    Granulocyte;    α-L-fucosyltransferase;    Blood group H gene;    Lymphocyte marker;   

DOI  :  10.1016/0014-5793(83)80308-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human lymphocytes and granulocytes were examined for blood group H-gene-specified α-2-L-fucosyl-transferase, α-3-L-fucosyltransferase and blood group Le-gene-specified α-4-L-fucosyltransferase. No α-4-L-fucosyltransferase was detectable in either cell type. α-3-L-Fucosyltransferase was readily demonstrable in both lymphocytes and granulocytes and the levels of activity per 10⁶ cells were approximately the same. In contrast, α-2L-fucosyltransferase was detectable in lymphocytes but not in similar numbers of granulocytes. The absence of α-2-L-fucosyltransferase was confirmed in granulocytes isolated from the blood of eighty unselected donors and was independent of ABO blood group or ABH secretor status.

【 授权许可】

Unknown