Islet‐activating protein discriminates the antilipolytic mechanism of insulin from that of other antilipolytic compounds

FEBS Letters

Jakobs, Karl H.¹  Aktor, Klaus¹  Kather, Horst²  Schulz, Günter¹ 

[1] Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, D-6900 Heidelberg, FRG;Klinisches Institut für Herzinfarktforschung an der Medizinischen Universitätsklinik Heidelberg, Bergheimer Str. 58, D-6900 Heidelberg, FRG

关键词: Insulin;    Islet-activating protein;    Rat adipocyte;    Lipolysis;    Adenylate cyclase;   

DOI  :  10.1016/0014-5793(83)80749-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In vivo administration of islet-activating protein to rats resulted in an increase in fat cell lipolysis in vitro, which was associated with almost complete resistance of adipocytes towards the antilipolytic effects of N ⁶-phenylisopropyladenosine, prostaglandin E₂ and nicotinic acid. Concomitantly, the inhibitory effects of these compounds on adenylate cyclase activity in membranes were impaired. In contrast, the antilipolytic action of insulin was not only preserved, but even augmented in cells from rats treated with islet-activating protein. The data suggest that insulin exerts its antilipolytic effects via mechanisms which are different from those involved in the effects of prostaglandin E₂, N ⁶-phenylisopropyladenosine and nicotinic acid.

【 授权许可】

Unknown