Interstrand DNA crosslinks due to AP (apurinic/apyrimidinic) sites

FEBS Letters

Goffin, Colette¹  Verly, Walter G.¹ 

[1] Biochimie, Faculté des Sciences, Université de Liège, Sart Tilman B6, 4000 Liège I, Belgium

关键词: AP site;    Interstrand DNA crosslink;    Ionizing radiation;   

DOI  :  10.1016/0014-5793(83)80747-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Storage of a solution of DNA containing apurinic sites, even at 4°C leads to the appearance of interstrand crosslinks. Possible biological consequences of these crosslinks, when they appear in cell DNA, are briefly discussed. Formation of interstrand crosslinks in DNA containing tritium-labelled thymine and kept in an aqueous solution might be due, at least partly, to the loss of bases by the autoirradiated DNA.

【 授权许可】

Unknown