Calcium‐induced Ca2+ release from sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia

FEBS Letters

Taylor, Stuart³  Gronert, Gerald A.¹  Tsuyoshi Ohnishi, S.² 

[1] Department of Anesthesiology, Mayo Medical School, Rochester, MN 55905, USA;Department of Hematology and Medical Oncology, Hahnemann University School of Medicine, Philadelphia PA 19102, USA;Department of Pharmacology, Rochester, MN 55905, USA

关键词: Calcium-induced calcium release;    Malignant hyperthermia;    Calcium release;    from sarcoplasmic reticulum;    Halothane;    Dantrolene;   

DOI  :  10.1016/0014-5793(83)80739-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Calcium-induced calcium release and halothane-induced calcium release from pig sarcoplasmic reticulum (SR) were studied. The SR prepared from pig susceptible to malignant hyperthermia (MH) was shown to release calcium at a much lower level of calcium content than in normal pig SR. The concentration above which halothane can release calcium is 40 μM for both MH-SR and normal SR, although the latter required a high calcium content to demonstrate the calcium release. Dantrolene was shown to inhibit the halothane-induced calcium release. Results suggests that SR plays an importnat role in pathogenesis of MH.

【 授权许可】

Unknown