Gene duplication in bovine brain myelin proteolipid and homology with related proteins

FEBS Letters

Samiullah, Mohammed¹  Laursen, Richard A.¹  Lees, Marjorie B.¹ 

[1] Department of Chemistry, Boston University, Boston, MA 02215, USA

关键词: Gene duplication;    Myelin proteolipid;    Membrane protein;    Myelin basic protein;    Po glycoprotein;    ATP synthase;   

DOI  :  10.1016/0014-5793(83)80732-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, P_o, and with the small proteolipid subunit of mitochondrial ATP synthase. These results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements, and that these elements are also found in non-myelin proteins. Furthermore, the proteolipid appears to have evolved by acquisition of elements from a ‘gene pool’ over a period of time, rather than by a simple duplication mechanism.

【 授权许可】

Unknown