Cyclic AMP, folic acid and pterin‐mediated protein carboxymethylation in cellular slime molds

FEBS Letters

van Waarde, Aren¹ 

[1] Cell Biology and Morphogenesis Unit, Zoological Laboratory, University of Leiden, Kaiserstraat 63, 2311 GP Leiden, The Netherlands

关键词: Protein carboxymethylation;    Chemotaxis;    Folic acid;    Monapterin;    Dictyostelium discoideum;    Dictyostelium lacteum;   

DOI  :  10.1016/0014-5793(83)80727-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In aggregative cells of Dictyostelium discoideum, extracellular cAMP induces transient methylation of a M _r 46 000 protein. Starvation induces a 10–100-fold increase in the number of cAMP-receptors, but no change in the amount of the methyl accepting protein. In vegetative amoebae, a temporal increase of methylation of the protein is induced by stimulation with folic acid. Aggregative amoebae of Dictyostelium lacteum also contain a M _r 46 000 protein, which is methylated after addition of the attractant monapterin. Therefore, protein carboxymethylation seems to be a general phenomenon during chemotaxis of the cellular slime molds.

【 授权许可】

Unknown