期刊论文详细信息
FEBS Letters | |
Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon | |
McCormack, J.G.1  Assimacopoulos-Jeannet, F.2  Jeanrenaud, B.2  | |
[1] Department of Biochemistry, University of Bristol Medical School, University Walk, Bristol BS8 1TD, England;Laboratoires de Recherches Métabolique, University of Geneva Medical School, 64, Avenue de la Roseraie, 1211 Geneva 4, Switzerland | |
关键词: (Liver); Pyruvate dehydrogenase; α1-Adrenergic receptor; Glucagon; Ca2+; Ionophore A23187; | |
DOI : 10.1016/0014-5793(83)80421-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In isolated rat hepatocytes phenylephrine promotes a rapid increase in the amount of pyruvate dehydrogenase present in its active form (PDHa). This action is mediated by α1-adrenergic receptors and is not observed in Ca2+-depleted hepatocytes. It is mimicked by the Ca2+ ionophore A23187. No changes in metabolites known to affect PDH activity are measured 3 min after addition of phenylephrine. Glucagon also increases PDHa, its action is additive to that of phenylephrine. The action of phenylephrine on PDHa could be explained by an increase in mitochondrial free Ca2+.
【 授权许可】
Unknown
【 预 览 】
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