GDP does not support activation of adenylate cyclase nor ADP‐ribosylation of a guanine nucleotide binding protein by cholera toxin

FEBS Letters

Kimura, Narimichi¹  Shimada, Nobuko¹ 

[1] Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-cho, Itabashi-ku, Tokyo, Japan

关键词: Cholera toxin;    Adenylate cyclase;    GDP;    ADP-ribosylation;    Liver plasma membrane;   

DOI  :  10.1016/0014-5793(83)80419-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The actions of cholera toxin (i.e., activation of adenylate cyclase and ADP-ribosylation of a guanine nucleotide binding protein in purified membranes fronm rat liver) were GTP dependent. Neither of these actions of cholera toxin was reproduced with GDP. Simultaneous addition of ATP and MgCl₂ along with GDP allowed cholera toxin to exert these actions. The role of GDP in adenylate cyclase regulation was discussed.

【 授权许可】

Unknown