期刊论文详细信息
FEBS Letters | |
GDP does not support activation of adenylate cyclase nor ADP‐ribosylation of a guanine nucleotide binding protein by cholera toxin | |
Kimura, Narimichi1  Shimada, Nobuko1  | |
[1] Department of Biochemistry, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakae-cho, Itabashi-ku, Tokyo, Japan | |
关键词: Cholera toxin; Adenylate cyclase; GDP; ADP-ribosylation; Liver plasma membrane; | |
DOI : 10.1016/0014-5793(83)80419-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The actions of cholera toxin (i.e., activation of adenylate cyclase and ADP-ribosylation of a guanine nucleotide binding protein in purified membranes fronm rat liver) were GTP dependent. Neither of these actions of cholera toxin was reproduced with GDP. Simultaneous addition of ATP and MgCl2 along with GDP allowed cholera toxin to exert these actions. The role of GDP in adenylate cyclase regulation was discussed.
【 授权许可】
Unknown
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