Phosphoenolpyruvate shuttle ‐ transport of energy from mitochondria to cytosol

FEBS Letters

Rauchová, Hana¹  Miková, Marie¹  Bass, Arnošt¹  Drahota, Zdeněk¹  Kaul, Phool¹ 

[1] Institute of Physiology, Czechoslovak Academy of Sciences, Prague 4, Czechoslovakia

关键词: Phosphoenolpyruvate: Brown fat mitochondria;    Phosphoenolpyruvate carboxykinase;    Energy transformation;   

DOI  :  10.1016/0014-5793(83)80573-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Brown-adipose tissue mitochondria of hamster and rat contain phosphoenolpyruvate carboxykinase (EC 4.1.1.32). In the presence of ketoglutarate and malate, phosphoenolpyruvate is formed and exported forms mitochondria. Phosphoenolpyruvate formation is inhibited by 1,2,3-benzenetricarboxylate. It is proposed that phosphoenolpyruvate carboxykinase together with pyruvate carboxylase and pyruvate kinase forms a phosphoenolpyruvate shuttle through which energy produced by the Krebs cycle in mitochondria may be exported to cytosol.

【 授权许可】

Unknown