Further characterization of the bile salt‐stimulated lipase in human milk

FEBS Letters

Bläckberg, Lars²  Hernell, Olle¹ 

[1] Departments of Physiological Chemistry and Pedriatics, University of Umeå, S-901 87 Umeå, Sweden

关键词: Bile salt-stimulated lipase;    Human milk;    Lipid digestion;    Newborn infant;   

DOI  :  10.1016/0014-5793(83)80571-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bile salt-stimulated lipase is a milk enzyme unique to the higher primates. Its molecular and kinetic characteristics differ greatly from other lipolytic enzymes; e.g., pancreatic lipase and lipoprotein lipase. It has a much higher app. M _r, 310 000 on gel filtration and 100 000 after denaturation. It requires primary bile salts for optimal activity and bile salts also protect the enzyme from proteolytic and heat inactivation. It may, due to its low substrate specificity, contribute to the utilization of a variety of milk lipids. Since it lacks positional specificity, digestion of milk triglycerides should be complete, which may explain why fat absorption is more efficient in breast-fed than in formula-fed infants.

【 授权许可】

Unknown