Gossypol binds to a high‐affinity binding site on human serum albumin

FEBS Letters

Royer, Robert E.¹  Vander Jagt, David L.¹ 

[1] Department of Biochemistry, The University of New Mexico, School of Medicine, Albuquerque, New Mexico 87131, USA

关键词: Albumin;    Glutathione S-transferase;    Gossypol;    Bilirubin;   

DOI  :  10.1016/0014-5793(83)81109-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The triterpene gossypol competes with bilirubin for a high-affinity binding site on human serum albumin. Similar competition between bilirubin and gossypol occurs in the binding of these ligands to the glutathione S-transferases from human liver and placenta. In each case, gossypol and bilirubin exhibit similar binding constants. The binding properties of gossypol may generally mimic those of bilirubin.

【 授权许可】

Unknown