Effect of starvation on the N‐acetylglutamate system of rat liver

FEBS Letters

Jordá, A.²  Cabo, J.¹  Gomez, M.¹  Grisolía, S.² 

[1] Departamento de Bioquímica de la Facultad de Farmacia de Valencia, Amadeo de Saboya, 4, Valentia-10, Spain;Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Spain

关键词: Carbamylphosphate synthetase;    Ornithine transcarbamylase;    N-Acetylglutamate synthetase;    N-Acetylglutamate deacylase;    N-Acetylglutamate;    Arginine;   

DOI  :  10.1016/0014-5793(83)80260-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rats fasted for 3 and 6 days showed an increase in the activity, per g of liver but not per total liver, of the mitochondrial urea cycle enzymes, carbamylphopshate synthetase and ornithine transcarbamylase. The activity of N-acetylglutamate synthetase, both per g and per total liver, increased by the third day and then decreased on the sixth day of fasting. The cytosolic enzyme N-acetyldeacylase showed the same general pattern as the N-acetylglutamate synthetase except that the relative proportion of synthetase over deacylase was higher at the third day of starvation. The N-acetylglutamate level/g liver increases in relation to the number of days of fasting.

【 授权许可】

Unknown