Urea cycle disorder in C3H‐H‐2° mice with juvenile steatosis of viscera

FEBS Letters

Saheki, Takeyori¹  Arakawa, Hiroyuki¹  Noda, Takashi¹  Koizumi, Tsutomu²  Imamura, Yasushi¹  Nikaido, Hiroko²  Hayakawa, Jun-ichiro² 

[1] Institute forExperimental Animals, School of Medicine, Kanazawa University, 13-1, Takaramachi, Kanazawa 920, Japan;First Department of Biochemistry, Faculty of Medicine, Kagoshima University, 1208, Usuki-cho, Kagoshima 890 Japan

关键词: Steatosis;    Hyperammonemia;    Urea cycle;    Gene expression;    Carbamylphosphate synthetase;    (Animal model);   

DOI  :  10.1016/0014-5793(90)80081-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We determined the activities of urea cycle enzymes in the liver of C3H-H-2^o-jsv mice. The activities of all urea cycle enzymes decreased in the latter period of lactation. The activities of carbamylphosphate synthetase and ornithine transcarbamylase in some affected mice were undetectable. On the other hand, the activities of enzymes other than urea cycle enzymes were normal. We consider that the decrease in the urea cycle enzymes is caused by an abnormality in the mechanism of gene expression.

【 授权许可】

Unknown