Melittin‐induced fusion of acidic liposomes

FEBS Letters

Eytan, Gera D.¹  Almary, Taiser¹ 

[1] Department of Biology, Technion — Israel Institute of Technology, Haifa 32000, Israel

关键词: Fusion;    Liposome;    Melittin;    Cardiolipin;   

DOI  :  10.1016/0014-5793(83)80241-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Melittin-induced fusion of acidic liposomes. Fusion was observed in the electron-microscope and assayed as intermixing of both liposomes' contents and membranes. The melittin concentrations required for fusion induction were in the μM range compared to over 10 mM Ca²⁺ required for a comparable effect. It is suggested that the high efficiency of melittin is due to its amphipathic nature. Its hydrophobic moiety is probably anchored in one liposome while the positively charged hydrophilic moiety attracts another liposome.

【 授权许可】

Unknown