FEBS Letters | |
Effect of b‐itc 1‐site inhibitors on the midpoint potentials of mitochondrial cytochromes b | |
Kunz, Wolfram S.1  Konstantinov, Alexander A.2  | |
[1] Institut für Physiologische Chemie, Medizinische Akademie Magdeburg, Leipziger Str. 44, Magdeburg, GDR;A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Moscow, 117234, USSR | |
关键词: Respiratory chain; Cytochrome b; Redox titration; 2-Alkyl-4-hydroxyquinoline N-oxide; Funiculosin; Myxothiazol; HpHOQnO; 2-n-heptyl-4-hydroxyquinoline N-oxide; NoHOQnO; 2-n-nonyl-4-hydroxyquinoline N-oxide; SMP; submitochondrial particles; | |
DOI : 10.1016/0014-5793(82)80611-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Anaerobic potentiometric titrations of b cytochromes have been carried out in beef heart submitochondrial particles in the presence of several specific inhibitors of electron transfer through the b-c 1-site of the respiratory chain. Whereas antimycin shows no significant effect on the titration curve of cytochrome b-562, NoHOQnO is found to shift the E m of b-562 by 20–30 mV to the positive. Funiculosin raises the E m of b-562 by > 100 mV and also appears to bring about a minor shift of b-566 midpoint potential. In the presence of myxothiazol, both b cytochromes with E m values 15–30 mV more positive than in the control.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020284251ZK.pdf | 408KB | download |