期刊论文详细信息
FEBS Letters
Effect of b‐itc 1‐site inhibitors on the midpoint potentials of mitochondrial cytochromes b
Kunz, Wolfram S.1  Konstantinov, Alexander A.2 
[1] Institut für Physiologische Chemie, Medizinische Akademie Magdeburg, Leipziger Str. 44, Magdeburg, GDR;A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Moscow, 117234, USSR
关键词: Respiratory chain;    Cytochrome b;    Redox titration;    2-Alkyl-4-hydroxyquinoline N-oxide;    Funiculosin;    Myxothiazol;    HpHOQnO;    2-n-heptyl-4-hydroxyquinoline N-oxide;    NoHOQnO;    2-n-nonyl-4-hydroxyquinoline N-oxide;    SMP;    submitochondrial particles;   
DOI  :  10.1016/0014-5793(82)80611-X
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Anaerobic potentiometric titrations of b cytochromes have been carried out in beef heart submitochondrial particles in the presence of several specific inhibitors of electron transfer through the b-c 1-site of the respiratory chain. Whereas antimycin shows no significant effect on the titration curve of cytochrome b-562, NoHOQnO is found to shift the E m of b-562 by 20–30 mV to the positive. Funiculosin raises the E m of b-562 by > 100 mV and also appears to bring about a minor shift of b-566 midpoint potential. In the presence of myxothiazol, both b cytochromes with E m values 15–30 mV more positive than in the control.

【 授权许可】

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