Relationships between the effects of redox potential, α‐Thenoyltrifluoroacetone and malonate on O2 − and H2O2 generation by submitochondrial particles in the presence of succinate and antimycin

FEBS Letters

Tikhonov, Alexander N.¹  Ksenzenko, Marina¹  Khomutov, Gennadiy B.¹  Konstantinov, Alexander A.¹  Ruuge, E.K.¹ 

[1] A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Moscow, 119899 USSR

关键词: Respiratory;    chain;    Superoxide;    generation;    Redox titration;    α-thenoyltrifluoroacetone;    Ubisemiquinone;    Q-cycle;    TTFA;    α-thenoyltrifluoroacetone;    SMP;    submitochondrial particles;    QH·;    ubisemiquinone;   

DOI  :  10.1016/0014-5793(84)80579-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The rate of the antimycin-induced H₂O₂ and O₂ ^XXXgeneration in beef heart submitochondrial particles is maximal at the [succinate]/[fumarate] ratio of 1:5 and decays at both higher and lower redox potentials. Succinate dehydrogenase inhibitors, such as TTFA or malonate, stimulate active oxygen production in the presence of excess succinate but are inhibitory at E _h, values more positive than the optimal. The modulation of O₂ ^xxx and H₂O₂ generation by these inhibitors can be explained by their effects on the steady-state redox potential(s) of the component(s) of mitochondrial site 2.

【 授权许可】

Unknown