Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon

FEBS Letters

Chatzipanteli, Katina¹  Saggerson, David¹ 

[1] Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, England

关键词: Adenosine deaminase;    Adipocyte;    Diabetes;    Glucagon;    Lipolysis;    Streptozotocin;   

DOI  :  10.1016/0014-5793(83)80225-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adipocytes from streptozotocin-diabetic rats are ∼50-times more sensitive to the lipolytic action of glucagon. This change is only perceived in the presence of a small quantity of adenosine deaminase which itself has little effect on basal lipolysis. Insulin treatment restores glucagon sensitivity to normal.

【 授权许可】

Unknown