Interaction of neuroleptic drugs with a synthetic calcium‐binding peptide analog of site III of rabbit skeletal troponin C

FEBS Letters

Hodges, Robert S.¹  Reid, Ronald E.¹  Gariépy, Jean¹ 

[1] Medical Research Council Group in Protein Structure and Function Department of Biochemistry, University of Alberta, Edmondon, Alberta T6G 2H7, Canada

关键词: Circular dichroism;    Drug binding;    Synthetic peptide;    Troponin C;    CaM;    calmodulin;    cAMP;    3′-5′ cyclic adenosine monophosphate;    CD;    circular dichroism;    EGTA;    ethylene glycol bis (β-aminoethyl ether);    N;    N;    N′;    N′-tetraacetic acid;    MOPS;    3-(N-morpholino) propanesulfonic acid;    TnC;    troponin C;   

DOI  :  10.1016/0014-5793(83)80875-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III or rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD-detectable structural change in the apopeptide but prevented Ca²⁺-induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca²⁺-induced structural change.

【 授权许可】

Unknown